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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Autoimmunthyreopathie</span></h1>
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<td style="min-width:8ex;">E06.3
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<td>Autoimmunthyreopathie
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<td><span style="display:none;">Vorlage:Infobox ICD/Wartung</span>
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<td colspan="2" style="border-top:0.2ex solid #CCCCCC; padding:.4ex 1ex .4ex 0; text-align:center; vertical-align:top;"><a rel="nofollow" class="external text" href="https://klassifikationen.bfarm.de/icd-10-who/kode-suche/htmlamtl2019/index.htm">ICD-10 online (WHO-Version 2019)</a>
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<th colspan="2" style="background:#99CCFF; color:#000000; text-align:center; font-size:115%; border:2px solid #99CCFF;">Klassifikation nach <a href="ICD-11" title="ICD-11">ICD-11</a>
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<td style="min-width:8ex;">5A03.2
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<td>Autoimmunthyreoiditis
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<td colspan="2" style="border-top:0.2ex solid #CCCCCC; padding:.4ex 1ex .4ex 0; text-align:center; vertical-align:top;">ICD-11: <a rel="nofollow" class="external text" href="https://icd.who.int/browse/latest-release/mms/en">Englisch</a> • <a rel="nofollow" class="external text" href="https://www.bfarm.de/DE/Kodiersysteme/Klassifikationen/ICD/ICD-11/uebersetzung/_node.html">Deutsch (Entwurf)</a>
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<p><b>Autoimmunthyreopathien</b> (<span style="font-style:normal;font-weight:normal"><a href="Englische_Sprache" title="Englische Sprache">englisch</a></span> <span lang="en-Latn" style="font-style:italic">autoimmune thyroiditis</span>) sind chronisch entzündliche <a href="Schilddr%C3%BCse" title="Schilddrüse">Schilddrüsen</a>erkrankungen, die durch eine Fehlregulation der spezifischen <a href="Immunabwehr" class="mw-redirect" title="Immunabwehr">Immunabwehr</a> (<a href="B-Zelle" class="mw-redirect" title="B-Zelle">B-Zellen</a> und <a href="T-Zelle" class="mw-redirect" title="T-Zelle">T-Zellen</a>) verursacht sind. Meist treten Autoimmunthyreopathien nach Virusinfekten auf, gelegentlich auch nach einer subakuten <a href="Thyreoiditis" title="Thyreoiditis">Thyreoiditis</a>. Genetische Faktoren spielen für ihre Entwicklung eine Rolle.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Einteilung">Einteilung</h2></div>
<p>Folgende Einteilung wurde vorgeschlagen:<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>
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<ul><li>Typ 1: <a href="Euthyreose" title="Euthyreose">euthyreote Stoffwechsellage</a>
<ul><li>1A: mit Struma (<a href="Hashimoto-Thyreoiditis" title="Hashimoto-Thyreoiditis">Hashimoto-Thyreoiditis</a>)</li>
<li>1B: ohne Struma (<a href="Ord-Thyreoiditis" class="mw-redirect" title="Ord-Thyreoiditis">Ord-Thyreoiditis</a>)</li></ul></li>
<li>Typ 2: <a href="Hypothyreose" title="Hypothyreose">Hypothyreose</a>
<ul><li>2A: mit Struma (<a href="Hashimoto-Thyreoiditis" title="Hashimoto-Thyreoiditis">Hashimoto-Thyreoiditis</a>)</li>
<li>2B: ohne Struma (<a href="Ord-Thyreoiditis" class="mw-redirect" title="Ord-Thyreoiditis">Ord-Thyreoiditis</a>)</li></ul></li>
<li>Typ 3: <a href="Morbus_Basedow" title="Morbus Basedow">Morbus Basedow</a>
<ul><li>3A: mit <a href="Hyperthyreose" title="Hyperthyreose">Hyperthyreose</a></li>
<li>3B: mit <a href="Euthyreose" title="Euthyreose">euthyreoter Stoffwechsellage</a></li>
<li>3C: mit <a href="Hypothyreose" title="Hypothyreose">Hypothyreose</a></li></ul></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Psychische_Begleitsymptome">Psychische Begleitsymptome</h2></div>
<p>Antikörper gegen Schilddrüsengewebe lassen sich vermehrt in Patienten mit <a href="Depression" title="Depression">Depression</a> nachweisen.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Eine Autoimmun-Thyreoiditis tritt häufig gepaart mit einer <a href="Bipolare_St%C3%B6rung" title="Bipolare Störung">bipolaren Störung</a> auf. Kausalitäten mit der oft angewandten <a href="Lithiumtherapie" title="Lithiumtherapie">Lithiumtherapie</a> der Patienten konnte dabei ausgeschlossen werden.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Eine Autoimmun-Thyreoiditis ist ein Teil der genetischen Anfälligkeit und ein möglicher Endophänotyp für eine bipolare Störung.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">Matthias Schott, Werner A. Scherbaum: <a rel="nofollow" class="external text" href="https://www.aerzteblatt.de/pdf/103/45/a3023.pdf">Autoimmune Schilddrüsenerkrankungen</a>, <a href="Deutsches_%C3%84rzteblatt" title="Deutsches Ärzteblatt">Deutsches Ärzteblatt</a>, Jg. 103, Heft 45, 10. November 2006</span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">Terry F. Davies, Nobuyuki Amino: <cite style="font-style:italic">A New Classification for Human Autoimmune Thyroid Disease</cite>. In: <cite style="font-style:italic">Thyroid</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>3</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>4</span>, 1993, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>331–333</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1089/thy.1993.3.331">10.1089/thy.1993.3.331</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:Autoimmunthyreopathie&amp;rft.atitle=A+New+Classification+for+Human+Autoimmune+Thyroid+Disease&amp;rft.au=Terry+F.+Davies%2C+Nobuyuki+Amino&amp;rft.date=1993&amp;rft.doi=10.1089%2Fthy.1993.3.331&amp;rft.genre=journal&amp;rft.issue=4&amp;rft.jtitle=Thyroid&amp;rft.pages=331-333&amp;rft.volume=3" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><cite style="font-style:italic">Antithyroid antibodies in depressed patients</cite>. In: <cite style="font-style:italic">American Journal of Psychiatry</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>142</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>7</span>, 1985, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>840–843</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1176/ajp.142.7.840">10.1176/ajp.142.7.840</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:Autoimmunthyreopathie&amp;rft.atitle=Antithyroid+antibodies+in+depressed+patients&amp;rft.date=1985&amp;rft.doi=10.1176%2Fajp.142.7.840&amp;rft.genre=journal&amp;rft.issue=7&amp;rft.jtitle=American+Journal+of+Psychiatry&amp;rft.pages=840-843&amp;rft.volume=142" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">Ralph W Kupka, Willem A Nolen, Robert M Post, Susan L McElroy, Lori L Altshuler, Kirk D Denicoff, Mark A Frye, Paul E Keck, Gabriele S Leverich, A.John Rush, Trisha Suppes, Chad Pollio, Hemmo A Drexhage: <cite style="font-style:italic">High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure</cite>. In: <cite style="font-style:italic">Biological Psychiatry</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>51</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>4</span>, 2002, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>305–311</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/S0006-3223%2801%2901217-3">10.1016/S0006-3223(01)01217-3</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:Autoimmunthyreopathie&amp;rft.atitle=High+rate+of+autoimmune+thyroiditis+in+bipolar+disorder%3A+lack+of+association+with+lithium+exposure&amp;rft.au=Ralph+W+Kupka%2C+Willem+A+Nolen%2C+Robert+M+Post%2C+...&amp;rft.date=2002&amp;rft.doi=10.1016%2FS0006-3223%2801%2901217-3&amp;rft.genre=journal&amp;rft.issue=4&amp;rft.jtitle=Biological+Psychiatry&amp;rft.pages=305-311&amp;rft.volume=51" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">John J. Haggerty, Susan G. Silva, Mark Marquardt, George A. Mason, Hsing Yi Chang, Dwight L. Evans, Robert N. Golden, Cort Pedersen: <cite style="font-style:italic">Prevalence of antithyroid antibodies in mood disorders</cite>. In: <cite style="font-style:italic">Depression and Anxiety</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>5</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>2</span>, April 1997, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>91–96</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/%28SICI%291520-6394%281997%295%3A23.0.CO%3B2-8">10.1002/(SICI)1520-6394(1997)5:23.0.CO;2-8</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:Autoimmunthyreopathie&amp;rft.atitle=Prevalence+of+antithyroid+antibodies+in+mood+disorders&amp;rft.au=John+J.+Haggerty%2C+Susan+G.+Silva%2C+Mark+Marquardt%2C+...&amp;rft.date=1997-04&amp;rft.doi=10.1002%2F%28SICI%291520-6394%281997%295%3A23.0.CO%3B2-8&amp;rft.genre=journal&amp;rft.issue=2&amp;rft.jtitle=Depression+and+Anxiety&amp;rft.pages=91-96&amp;rft.volume=5" style="display:none">&nbsp;</span></span>
</li>
<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text">Ronald Vonk, Astrid C. van der Schot, René S. Kahn, Willem A. Nolen, Hemmo A. Drexhage: <cite style="font-style:italic">Is Autoimmune Thyroiditis Part of the Genetic Vulnerability (or an Endophenotype) for Bipolar Disorder?</cite> In: <cite style="font-style:italic"><a href="Biological_Psychiatry" title="Biological Psychiatry">Biological Psychiatry</a></cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em">&nbsp;</span>62</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em">&nbsp;</span>2</span>, 2007, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em">&nbsp;</span>135–140</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.biopsych.2006.08.041">10.1016/j.biopsych.2006.08.041</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rfr_id=info:sid/de.wikipedia.org:Autoimmunthyreopathie&amp;rft.atitle=Is+Autoimmune+Thyroiditis+Part+of+the+Genetic+Vulnerability+%28or+an+Endophenotype%29+for+Bipolar+Disorder%3F&amp;rft.au=Ronald+Vonk%2C+Astrid+C.+van+der+Schot%2C+Ren%C3%A9+S.+Kahn%2C+...&amp;rft.date=2007&amp;rft.doi=10.1016%2Fj.biopsych.2006.08.041&amp;rft.genre=journal&amp;rft.issue=2&amp;rft.jtitle=Biological+Psychiatry&amp;rft.pages=135-140&amp;rft.volume=62" style="display:none">&nbsp;</span></span>
</li>
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